I am a medical school professor, research scientist, consultant, inventor, and amateur photographer. I teach, do research, and provide professional service in the Department of Pathology and Microbiology at The University of Nebraska Medical Center. Consulting and business activities not associated with the university are done through IRBF Development, LLC.


Research and Teaching



I enjoy work in the lab, and I continue to do what I enjoy. I remain interested in blood coagulation, which I studied for over 20 years, but my current research is focused on group B coxsackieviruses and their receptor (Carson, Chapman, and Tracy, 1997; Carson, Chapman, Hafenstein, and Tracy, 2011). The group B coxsackieviruses can cause serious infections of the heart (myocarditis), pancreas (pancreatitis, and possibly diabetes), and brain (encephalitis), and can be particularly dangerous in babies. My current research investigates molecules that bind group B coxsackieviruses, their effects on virus viability/stability, and how they alter the interaction of the viruses with the CAR (coxsackievirus and adenovirus receptor) and with cells (Organtini et al, 2014; Carson, 2014). I am increasingly curious about selective pressures that drive these viruses to bind molecules other than the CAR (Carson, Chapman, Hafenstein, and Tracy, 2011), and mechanisms that affect virus stability and efficiency for infecting target cells (Carson et al, 2016).



Dr. Sam Pirruccello and I coordinate four hours of lectures in the Blood Organ Core of the first year medical curriculum. I teach the fundamental biochemistry of blood coagulation, fibrinolysis, and their regulation. This introduces the students to platelets, enzymes, cofactors, inhibitors, and other proteins that participate in hemostasis, and the basic principles involved in regulation (e.g. activation, feedback loops, inhibition). This prepares them with the vocabulary and concepts necessary to appreciate Dr. Pirruccello's lectures on clinical bleeding and clinical thrombosis.

In the Graduate College, Dr. Maurice Godfrey and I have teamed together to teach Molecular Basis of Disease. This is a three-credit upper-level graduate course concentrating on human biochemical genetics. Following a brief review of genetic principles, well-studied inborn errors of metabolism and development are used to illustrate how genetic variations (e.g. mutations) alter metabolic, developmental, or signaling systems and result in the expressed phenotype. Disease processes are considered in the context of environment and genetic diversity. One-third of the course involves discussion of contemporary literature relevant to diseases for which mechanisms are not yet well understood or only recently elucidated. Dr. Lois Starr, a clinical geneticist, is a co-director of the course as of 2016. Her clinical expertise provides a new dimension to the course.

Additional involvement in graduate education includes past decades of service on the Pathology and Microbiology Graduate Committee, and participation on student supervisory committees.

Instructional and Informational Pages:

Calculate TCID50/mL
PAMM 940 Molecular Basis of Disease
Group B Coxsackievirus Capsids -- Lab mutants
Wall Quotes
Cost of Writing Grant Proposals
Monoclonal antibodies against CAR (coxsackievirus and adenovirus receptor)
Continuous chromogenic rate assay for Tissue Factor, Factor VII, or Factor X
Web Presentations adapted from PowerPoint
Basics of Enzyme Kinetics from Dr. J. Jesty PDF